GW-0742 Powder

A. Introduction

GW-0742 is an essential research tool used to investigate the physiological roles of the PPARδ isoform. Due to its high potency and selectivity (1000-fold over other PPAR subtypes), it is a preferred ligand for laboratories exploring the regulation of fatty acid metabolism, inflammation, and energy homeostasis in various tissue models.

B. Scientific Overview

Chemically identified as [4-[[[2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy]acetic acid ($C_{21}H_{17}F_{4}NO_{3}S_{2}$), GW-0742 differs from GW-501516 by the addition of a fluorine atom at the 3-position of the phenyl ring. In research settings, it is utilized to activate the PPARδ-mediated transcriptional program, which oversees the expression of proteins involved in mitochondrial biogenesis and cholesterol transport.

C. Product Specifications

• Form: Crystalline powder

• Chemical Class: PPARβ/δ Agonist / Thiazole derivative

• Molecular Formula: $C_{21}H_{17}F_{4}NO_{3}S_{2}$

• Molecular Weight: 471.5 g/mol

• Purity: ≥99% (HPLC/NMR Verified)

• Solubility: Soluble in DMSO (up to 25 mg/mL) and Ethanol

• Storage: Store at room temperature (15°C to 25°C) in a dry, airtight container protected from light.

D. Laboratory Use Context

GW-0742 powder is provided exclusively for in-vitro research and analytical testing. It is an ideal reagent for:

• Investigating PPARδ-dependent gene expression in cardiac and skeletal muscle cultures.

• Studying the molecular pathways of glucose utilization and lipid oxidation.

• Calibration and validation of LC-MS and GC-MS equipment.

• Comparative structural analysis between halogenated PPAR ligands.

E. Quality & Testing

• HPLC Verification: Every batch is rigorously tested to confirm high chemical purity and exact molecular composition.

• Structural Identity: Mass Spectrometry (MS) and Proton NMR verify the presence of the trifluoromethyl-fluorophenyl-thiazole structure.

• Batch Consistency: Manufactured under strict protocols to ensure reproducible results for complex longitudinal studies.

• COA: Comprehensive Certificates of Analysis are provided for all institutional research requirements.

F. Shipping & Handling

Our GW-0742 powder is dispatched in professional, moisture-proof, and UV-protected packaging to maintain chemical integrity during transit. We offer reliable, discreet worldwide shipping to support the requirements of international research facilities and commercial laboratories.

G. Compliance Disclaimer (CLEAR & PROMINENT)

FOR RESEARCH USE ONLY. NOT FOR HUMAN CONSUMPTION. This product is a research chemical and is strictly intended for in-vitro laboratory applications and analytical testing. It is not intended for diagnostic or therapeutic use in humans or animals. No medical instructions or dosages are provided. The purchaser is solely responsible for compliance with all local and international laws regarding the acquisition and handling of this substance.