SR-9011 Capsules

A. Introduction

SR-9011 is a second-generation Rev-ErbA agonist developed to investigate the pharmacological modulation of the mammalian molecular clock. As a more potent analogue of SR-9009, it serves as a critical tool for research institutions studying the intersection of circadian biology and energy expenditure in various cellular models.

B. Scientific Overview

Chemically identified as 3-[[[(4-chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-N-pentyl-1-pyrrolidinecarboxamide ($C_{23}H_{31}ClN_{4}O_{3}S$), SR-9011 functions by enhancing the constitutive repressor activity of Rev-ErbA. In laboratory settings, it is utilized to suppress the transcription of core clock genes, such as BMAL1 and CLOCK. Researchers utilize this compound to observe its effects on fatty acid oxidation, glucose utilization, and the regulation of pro-inflammatory cytokines in synchronized cell cultures.

C. Product Specifications

• Form: Encapsulated powder for laboratory measurement

• Active Concentration: 10mg per unit

• Chemical Class: Rev-ErbA Agonist / Pyrrolidine derivative

• Molecular Formula: $C_{23}H_{31}ClN_{4}O_{3}S$

• Molecular Weight: 479.04 g/mol

• Purity: ≥98% (HPLC Verified)

• Quantity: Available in standard laboratory counts

• Storage: Store in a cool, dry environment (15°C to 25°C) protected from direct sunlight and moisture.

D. Laboratory Use Context

SR-9011 capsules are provided exclusively for in-vitro research and analytical testing. They are a vital reagent for:

• Investigating Rev-ErbA-mediated gene expression in metabolic tissue models.

• Studying the molecular mechanisms of circadian rhythm disruption and recovery.

• Calibration and validation of LC-MS/MS and GC-MS equipment for performance-enhancing substance screening.

• Comparative analysis of synthetic ligands on nuclear receptor repressor activity.

E. Quality & Testing

• Analytical Precision: Each batch undergoes rigorous HPLC analysis to confirm chemical purity and 10mg concentration accuracy per capsule.

• Structural Identity: Mass Spectrometry (MS) and Proton NMR verify the presence of the chlorophenyl, nitrothienyl, and pyrrolidine structural components.

• Homogeneity: Advanced encapsulation ensures uniform reagent distribution, providing high reproducibility for longitudinal laboratory studies.

F. Shipping & Handling

Our SR-9011 capsules are dispatched in high-barrier, moisture-proof, and UV-protected packaging to maintain chemical stability during transit. We provide professional, discreet worldwide shipping to support the logistical needs of international research facilities and commercial laboratories.

G. Compliance Disclaimer (CLEAR & PROMINENT)

FOR RESEARCH USE ONLY. NOT FOR HUMAN CONSUMPTION. This product is a research chemical and is strictly for in-vitro laboratory applications and analytical testing. It is not intended for diagnostic or therapeutic use in humans or animals. No medical claims or dosages are provided. The purchaser assumes all responsibility for compliance with local and international regulations regarding the acquisition and handling of this substance.